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Wired together, change together: Spike timing modifies transmission in converging assemblies


Precise timing of neuronal spikes may lead to changes in synaptic connectivity and is thought to be crucial for learning and memory. However, the effect of spike timing on neuronal connectivity in the intact brain remains unknown. Using closed-loop optogenetic stimulation in CA1 of freely-moving mice, we generated new spike patterns between presynaptic pyramidal cells (PYRs) and postsynaptic parvalbumin-immunoreactive (PV) cells. This stimulation led to spike transmission changes which occurred together across all presynaptic PYRs connected to the same postsynaptic PV cell. The precise timing of all presynaptic and postsynaptic cells spikes impacted transmission changes. These findings reveal an unexpected plasticity mechanism, wherein spike timing of a whole cell assembly has a more substantial impact on effective connectivity than that of individual cell pairs.


Lidor Spivak, Shirly Someck, Amir Levi, Shir Sivroni, Eran Stark

Published: 2023

PMID: Preprint


P64-7. Janus P4-7

Research Area:

Developmental Neuroscience, Computational Neuroscience