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Hippocampo-cortical circuits for selective memory encoding, routing, and replay


Traditionally considered a homogeneous cell type, hippocampal pyramidal cells have been recently shown to be highly diverse. However, how this cellular diversity relates to the different hippocampal network computations that support memory-guided behavior is not yet known. We show that the anatomical identity of pyramidal cells is a major organizing principle of CA1 assembly dynamics, the emergence of memory replay, and cortical projection patterns in rats. Segregated pyramidal cell subpopulations encoded trajectory and choice-specific information or tracked changes in reward configuration respectively, and their activity was selectively read out by different cortical targets. Furthermore, distinct hippocampo-cortical assemblies coordinated the reactivation of complementary memory representations. These findings reveal the existence of specialized hippocampo-cortical subcircuits and provide a cellular mechanism that supports the computational flexibility and memory capacities of these structures.


Ryan E. Harvey, Heath L. Robinson, Can Liu, Azahara Olivia
,Antonio Fernandez-Ruiz

Published: 2023

PMID: 37196658



Research Area:

Cognitive and Behavioral Neuroscience, Computational Neuroscience