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The SomaFocus Series Webinars
A New Way to Study Organoid Function
Presented by Fan Wu, Ph.D. & CTO of Diagnostic Biochips
During the session, our CTO, Dr. Fan Wu, introduced SomaFocus and shared how the technology is enabling new approaches to measuring neural activity in intact 3D cultures.
A key focus of the presentation was our novel automated depth recording capability, designed to capture electrophysiological activity from within intact brain organoids. This approach aims to address a major limitation in the field—accessing functional activity beyond surface-level regions.
Dr. Wu also walked through real data from early adopters, highlighting how researchers are using SomaFocus to measure functional activity across different organoid models and experimental conditions. These case studies demonstrated the potential for more consistent, detailed insight into neural behavior without complex sample preparation.
Modeling Neural Dysfunction in Tourette Syndrome
Presented by Flora Vaccarino, MD, and Riya Rauthan, Ph.D. of Yale University
Dr. Vaccarino's lab has been at the forefront of using patient-derived brain organoids to study neurodevelopmental disorders. In this webinar, Dr. Vaccarino and her postdoctoral researcher, Dr. Rauthan, shared real electrophysiological data from Tourette syndrome organoid models and discussed how functional measurements can uncover disease-relevant phenotypes that may not be apparent through morphology alone.
Genetic Disorder Modeling and Biological Rescue in Cerebral Organoids
Presented by Kyle Fink, Ph.D. of the University of California, Davis
Dr. Fink discussed how patient-derived brain organoids are advancing research into rare genetic neurodevelopmental disorders. This webinar highlighted how organoid models provide insight into disease biology and how silicon probe-based depth recordings reveal complex oscillatory patterns, network activity, and disease-specific electrophysiological phenotypes within intact 3D neural tissue. Dr. Fink also explored emerging therapeutic approaches that leverage gene regulation and epigenetic editing to reverse or correct disease-associated phenotypes, demonstrating the potential of these strategies to advance disease modeling and therapeutic discovery