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The Applications of SomaFocus™
Assess Electrophysiological Function
Move beyond cell composition and gene expression to measure true physiological performance. With SomaFocus, you can detect whether organoids are forming functional networks and active circuits, track their maturation and activity from the core of the tissue outward, and assess whether a model is truly viable for downstream experiments, transplantation, or therapeutic testing.
Disease Model Discovery
Go beyond molecular markers to determine whether your organoids truly reproduce key physiological features of disease, such as excitatory/inhibitory imbalance or disrupted network synchrony. With access to functional data across the full 3D volume, SomaFocus enables analysis of network-level dysfunction and circuit disruption in models of Alzheimer’s, autism, epilepsy, and more. Complement your -omics data by asking the critical question: Does it function like the disease — not just express similar markers?
Therapeutic Screening and Drug Development
Measure real-time responses to drug candidates at both the circuit and cell-type level. By analyzing spike shape and morphology, you can identify which neural populations are affected — without slicing or plating. Use these functional insights to prioritize leads before committing to deeper in-vivo behavioral studies, streamlining the path from screening to discovery.